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(23 customer reviews)

Serrapeptase 80,000 SPU or 130,000 SPU Supports:

  • Respiratory Health*
  • Muscle, Joint & Tissue Health*

120 Capsules  80K SPU:   $49.98 Now  $39.98
300 Capsules 80K SPU:  $112.95 Now  $79.98
420 Capsules  80K SPU: $139.83 Now  $99.98

  60 Capsules 130K SPU:    $39.99 Now $34.99
120 Capsules 130K SPU:    $71.99 Now $59.98


Serrapeptase: Acid-Resistant Serrapeptase (Peptizyme SP® EN)

Serrapeptase is a powerful systemic enzyme supporting respiratory and sinus health. Serrapeptase contains Peptizyme SP® EN, which is resistant to the acidic conditions of the stomach, maximizing efficacy.*

Why Take AST Enzymes’ Serrapeptase
Serrapeptase supports healthy respiratory and sinus function, as well as muscle, joint and overall tissue health.*

The ingredient in this powerful systemic enzyme supports:

  • Healthy Respiratory System*
  • Sinus Health*
  • Muscle, Joint and Tissue Health*
  • Healthy Oxygen Levels*
  • Muscle Recovery*

What’s Inside Serrapeptase

Acid-Resistant Serrapeptase (Peptizyme SP® EN)

What is Serrapeptase?

Serrapeptase—also known as serratiopeptidase—is an enzyme belonging to the serine protease class.  As a protease, it breaks down proteins into smaller components called amino acids. Serrapeptase was originally discovered in the digestive tract of silkworms in the 1960s.  It is often called the “butterfly enzyme” because its strong fibrinolytic activity enabled the silkworm to dissolve its tough, fibrous cocoon when it was ready to emerge. This same fibrinolytic activity was identified to support human cardiovascular and inflammatory systems and has been consumed by humans for decades.

Serrapeptase is a concentrated natural proteolytic enzyme supplement. But we don’t use just any serrapeptase. Our ingredient, Peptizyme SP® EN, is specially formulated with an acid-resistant polymer which helps protect the delicate enzyme from the acidic conditions of the stomach, allowing delivery of significantly more activity to the small intestine, maximizing efficacy.*

Why Take Fibrinolytic Enzymes?

Imagine you scrape your knee – your blood immediately clots, and your body makes a scaffolding out of fibrin (a thread-like protein) to hold the clot in place. This acts as a natural bandage as the body heals. Your body uses fibrin to repair internal injuries too.

But your body also has to take down the fibrin scaffolding (a process called fibrinolysis). Your body naturally does this with an enzyme called plasmin, which breaks down the fibrin into parts the body can process. Healthy fibrinolysis is critical to manage pain, scarring and potential blood clots.

Fibrinolytic enzymes are proteases that break down the tough strings of fibrin protein. Supplementing with fibrinolytic enzymes can help your body maintain healthy fibrin metabolism.*

Why Choose AST Enzymes’ Serrapeptase

AST Enzymes’ Serrapeptase is the strongest in the world, unrivaled among products of its kind because it is packed with 130,000 SPU per capsule of our specially formulated Serrapeptase with an acid-resistant polymer to maximize its effectiveness (80K is also available).  It is manufactured in ISO 9001:2000 and NSF GMP certified facilities and undergoes rigorous quality testing.

How MAAC Acid-Resistant Polymer Makes AST Enzymes’ Serrapeptase Uniquely Effective

Your stomach is naturally acidic to help digest food. But not every supplement can tolerate that acidity. Some enzymes, like serrapeptase, are powerful but delicate. They need a special delivery system that helps protect them from stomach acid. The cutting-edge, pthalate-free, methyacrylic acid copolymer (MAAC) applied to this product increases potency by allowing more enzyme activity to pass through the stomach, delivering it into the small intestine, where it is most needed.

When evaluated by an independent third-party laboratory, AST’s MAAC-containing Serrapeptase was found to have enzyme activity significantly greater than regular serrapeptase after passing through the acidic conditions of the stomach, allowing for much greater efficacy.

MAAC is a food-grade compound that has been in use as an enteric coating in the pharmaceutical industry for over 50 years with no reported side effects. In fact, the European Food Safety Authority – an organization that conducted studies which led to the ban of six types of phthalates in personal care products in Europe in 2004 – has deemed MAAC safe for use as a coating agent in food supplements. 

As a science-first company, AST Enzymes uses acid-resistant Peptizyme SP® EN because it delivers the best enzymes in their best form.*

What Isn’t Inside AST’s Serrapeptase

Serrapeptase is free of pesticides, chemicals, preservatives, animal derivatives, dairy, yeast, fish or shellfish, peanuts, and tree nuts. All individual enzymes are kosher-certified ingredients, and suitable for vegetarians and vegans.

Serrapeptase is manufactured in the USA in NSF-certified facilities that follow cGMP guidelines, for the highest quality products.

How to Take Serrapeptase 80,000 SPU

Take on an empty stomach (30-60 minutes before or 2 hours after meals).

  • Days 1-5: Take 1 capsule, twice a day.
  • Days 6-12+: Take 2+ capsules, twice a day (if needed).

How to Take Serrapeptase 130,000 SPU

Take on an empty stomach (30-60 minutes before or 2 hours after meals).

  • Days 1-5: Take 1 capsule, twice a day.
  • Days 6-12+: Take 2+ capsules, twice a day (if needed).

Caution: If you are pregnant, nursing, taking any medication or under medical supervision, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

SKU: N/A Category:

Serrapeptase 80,000 SPU

Take on an empty stomach (30-60 minutes before or 2 hours after meals).

Day 1-5: Take 1 capsule, twice a day.

Day 6-12+: Take 2(+) capsules, twice a day (if needed).


Serrapeptase 130,000 SPU

Take on an empty stomach (30-60 minutes before or 2 hours after meals).

Day 1-5: Take 1 capsule, twice a day.

Day 6-12+: Take 2(+) capsules, twice a day (if needed).



What is systemic enzyme therapy?

Systemic enzyme therapy refers to the therapeutic use of natural enzymes to produce a desired effect. Systemic enzymes are absorbed from the small intestine where they enter the bloodstream and execute their effects on the entire body as a system.

What is a systemic proteolytic enzyme?

Proteolytic enzymes break down proteins into their building-blocks, which are called amino acids. Regular systemic proteolytic enzyme use can promote healthy circulation.

Why is it important to take Serrapeptase on an empty stomach?

Since most absorption occurs in the small intestine, the systemic enzymes must bypass the stomach to gain access there. If the enzymes are taken with food, they will likely begin working to break down your food within the stomach, rather than passing through to the small intestine. Taking systemic enzymes like Serrapeptase with food will compromise their absorption, as well as their effectiveness.

Does Serrapeptase have acid-resistance?

Yes, an acid-resistant polymer is applied to AST’s serrapeptase (Peptizyme SP® EN). While similar systemic enzymes may have the same active ingredients, most do not apply such a polymer. The purpose of this acid-resistant polymer is to protect the enzyme from the acidic environment of the stomach. When an acid-resistant polymer is applied to the enzymes, its activity is more likely to be preserved until it reaches the small intestine, where absorption into the bloodstream takes place. While this polymer can withstand the acidic environment of the stomach, the alkaline environment of the small intestine will disintegrate the acid-resistant polymer, allowing the enzyme to become active within the bloodstream.

Do you use phthalates in your acid-resistant polymer?

No, at AST Enzymes, we use Methacrylic Acid Copolymer (MAAC) for our acid-resistant polymer, which does not use or contain phthalates. Compared to other commonly used agents such as Cellulose Acetate Phthalate (CAP) and Hydroxypropyl Methycellulose Phthalate (HPMCP), MAAC is the most gastro-resistant and does not carry the same risks. Additionally, MAAC is considered GRAS (Generally Recognized as Safe) by the FDA and is approved for use by the European Food Safety Authority. To learn more about the acid-resistant polymer used in AST Enzymes’ products, please click the “Compare” tab.

How long should I take Peptizyme-SP before feeling results?

The length of time to experience the benefits of systemic enzymes varies by individual. Some people notice a difference within days. For others, it’s a week or 10 days. For long-term benefits, it’s important to take systemic enzymes consistently over several months.

New systemic enzyme users should start off slow, with one capsule, three times daily. After three to four days of proven tolerance, the dose can be increased to a 2 capsules, 3 times per day.  monitored, and dosage should be adjusted accordingly. Some consumers find their ideal dose between 9-12 capsules per day, while others only need 3-6. There are several factors that may affect required dosage, including:





Time of administration (better absorbed on an empty stomach)

Adherence to regimen

Nutritional state

What if I miss a dose?

Regular, consistent use of systemic enzymes will provide the best results, however missed doses of systemic enzymes do not have serious repercussions. Although symptoms alleviated by systemic enzyme therapy may resurface, getting back on track by remembering to take your next dose will suffice. There is also the option of incorporating another dose during the day. There is no need to “double up” on one dose. Also remember, systemic enzymes are best absorbed on an empty stomach.

Does Serrapeptase have any side effects?

The use of Serrapeptase has not been shown to exhibit detrimental effects, long term or short term. Minor side effects may vary. Gastrointestinal disturbances have been reported by a small percentage of new users, but once the dosage is adjusted, tolerance is maintained. Minor allergic reactions, like reddening of the skin, are also rare occurrences, and can be seen with extremely high doses. There are no known interactions with prescription or over the counter drugs while using systemic enzyme therapy. However, it is recommended that you consult with your physician about starting systemic enzymes, particularly if you are on blood-thinning medications, or are pregnant or nursing.

Can I take Serrapeptase with other systemic enzymes?

Systemic enzymes may be taken together, yielding desirable results, as long as they are taken on an empty stomach. In fact, it is often recommended that systemic enzymes be combined. Supplements such as Serracor-NK and Serrapeptase often have synergistic effects when taken together. This means that the separate products work together to produce advantageous results. By combining and enhancing the activity of the enzymes, their effects on the healing process are more attainable.

Can I take Serrapeptase with digestive enzymes?

Although digestive and systemic enzymes are not contraindicated in terms of ingredients, they cannot be taken at the same time. The purpose of digestive enzymes is to aid in digestion of specific foods, so taking them with food is an obvious recommendation. Because systemic enzymes require an empty stomach for maximum absorption, they must be taken separately from digestive enzymes. There are no adverse interactions between systemic and digestive enzymes, but they serve different purposes and thus should be taken as directed for best results.

Based on 23 reviews

5.0 overall

Add a review

  1. Denise Kocourek

    We found your product while searching for something to support lung function for a respiratory problem of unknown origin. My mother used it for about 4 yrs and it did help her struggle. About 6 yrs ago, when I began to experience shortness of breath, I went to this product. So far, have not had to go on O2. Almost no coughing. It has been very supportive of my condition.

  2. Lina bannister

    I absolutely love this product -it has been a blessing n God send for any sinus n ear issues -I thank god for allowing me to find all of these enzymes -the product n customer service is great-I encourage u to try these for any sinus issues-u won’t be dissapointed-gods blessing to u all

  3. Carol T.

    I have been taking Serrapeptase for several years, and I am convinced it is keeping the adhesions away. (My surgeon said I was a prolific grower of scar tissue.) I had colon surgery when I was younger, and eight years later, I was doubled over in pain due to scar tissue strangling my intestines. It is now going on 14 years, and gratefully, I have been adhesion-free. YAY!

  4. Constance (verified owner)

    You have to try this product! My orthopedic surgeon told me it’s time for a shoulder replacement. Bike accident 20 years ago and the scar tissue was taking over my space. After one week on Serrapeptase my pain was gone. When I finally got into physical therapy they did the range of motion percents and asked me why I was there. ? No follow up appointments needed at either place?

  5. Tracey Shabazz (verified owner)

    This product is a consistent product in quality and value. My son was injured and we used is for his healing. Great improvement for his lungs, pain and digestion….

  6. Jacqueline Dollack

    My husband’s breathing problems have decreased remarkably since he began using Serrapeptase. We talk about its benefits to anyone who will listen.

  7. Jacqueline Dollack (verified owner)

    My husband uses Serrapeptase every day, and has since the first day he tried it. We feel that is saved his life. He had COPD and now he feels great most days. He recommends it to everyone, and any one who has used it has had success too. It worked so well for a friend with diabetes who hasn’t had one of his regular infections since he started using it two years ago. He swears by it now too, and tells everyone who will listen about it..

  8. Nicole Chamberlain, LMT,NTS

    I started using serrapeptase several years ago at the recommendation from a DOM. After further research, I switched to AST Enzymes because I felt it was a high quality product.
    I put AST to the test. I had an old abdominal scar that was deep and pulled on my deeper skin layer. After approximately 4 months, I noticed a significant improvement; less pain, less pulling. I appreciate a lot of the things serrapeptase can do! Great product!

  9. Jackie Green

    I started taking Serrapeptase shortly after discectomy surgery, I had been experiencing continued lower back pain and sciatica. Within a month of taking your product, my lower back pain was all but gone and sciatica much improved. I continue to take Serrapeptase which I believe keeps my sciatica under control. Thanks for an excellent product.

  10. Constance (verified owner)

    This enzyme is amazing! My lab, age 3, pulled a ” Bambi” on the ice last winter. Off and on he would limp for a few days then return to his normal running around. This past summer limping became the normal for him. I took him several times to a dog chiropractor and it would help for a couple of days then back to limping. I thought, a joint is a joint so I started him on your bottle. It has been a little over a week, I give him two capsules in the morning. His getting up is a lot better, no limping after laying down. I still walk him three miles every day and he seems so much better. The limping is miminal and he plays like the pup he is. You can just tell he feels better. Thank you again. Funny you don’t think about it but they have the same interior design as us!

  11. John B. (verified owner)

    Great supplement. I have some scar tissue from eye surgery, and it’s helping to heal the adhesions. Highly recommend!

  12. Abraham Fox (verified owner)

    I began taking Serrapeptase about 3 years ago after reading the late Dr. Hans Nieper’s writings on the subject. I have found great improvement in my memory and mental acuity since taking this enzyme. I’m near 80 years of age now but highly recommend serrapeptase for people of all ages.

  13. Becky Pratt (verified owner)

    This is a great addition to my health routine. I’ve noticed that I have more energy and recover more quickly after exercise. Also, my joints feel better.

  14. Donna Adams

    This product is great, it has greatly reduced inflammation in my system and I no longer have back pain! I like that it cleans out the ‘gunk’ in our blood. Great company.

  15. Alexis Pappas (verified owner)

    I was home bound before I used this product. These enzymes are high quality and I have recommended them to people. I highly recommend these enzymes.

  16. RONALD HARRIS (verified owner)

    This stuff is life changing for me. It allowed me to breath free. This stuff helped me when many other things did not. I love AST Enzymes Serrapeptase!
    R. Harris

  17. Sara Lashley (verified owner)

    I have been using your products, both the Serrapeptase and the Serracor-NK for over 6 years and I’ve noticed a clarity in my vision that had been declining for months. Since I haven’t done anything else, I do attribute this clarity to your Serrapeptase!

  18. Nicole Chamberlain

    I have an earlier review, but wanted to add that I also take serrapeptase for COPD. It prevents excess mucus and keeps my airways open. I switched to 130,000 units so I don’t have to take as many capsules.

  19. lhendrex (verified owner)

    My health care provider recommended Serrapeptase for the softening of severe scar tissue – both internal and external. He also recommended this product to dismantle the biofilm that was preventing effective treatment of a chronic, low grade infecting that was associated with the scar tissue. I had scarring and infection for 40 years without any success treating it. After using Serrapeptase for 1 year, I am noticing significant softening of the scar tissue and greater ease of movement. My doctor says that he has never seen my abdomen so soft and pliable, and I believe that this is due to my regular use of Serrapeptase.

  20. Jerry (verified owner)

    I had three herniated discs in my lower back and three in my neck on two separate occasions. I took more than recommended dosage, three times a day. After about a week, the pain was noticeably less. I lowered the dosage as the pain receded. I now take 240,000 units daily for maintenance, as I stopped taking it after the first incident. I had a cardio test recently and everything’s OK. No plaque in my arteries. Thanks AST!

  21. Tracey Shabazz (verified owner)

    Serrapeptase is a lfe long ritual that my son and I will take for life..Pain is keeped away since we began taking them in 2014 or so…

  22. Justin T (verified owner)

    I started using these because my girlfriend said she had more energy when she took them. After taking them for a few days, I actually felt better and calmer.

  23. Heather Mewis (verified owner)

    AST serrapeptase has changed my life. I have a neuroma in my left foot. I could hardly walk at one point. Didn’t want surgery. Finally found serrapeptase and eventually found AST brand which is consistent top quality and reasonable prices and great consumer service. I come again and again and recommend them to everyone.


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